MEDICINA RIGENERATIVA

RIGENERA-HBW™ è un dispositivo medico in grado di trasformare, attraverso una sola azione meccanica, un innesto, sia esso osseo, cartilagineo, muscolare o tissutale, in microinnesti di dimensioni pari a 70-80 micron, mantenendo al contempo una vitalità cellulare pressoché totale.

Il protocollo a micro-innesti con tecnologia RIGENERA-hbw è un approccio clinico innovativo volto alla rigenerazione dei tessuti: attraverso micro-innesti ottenuti tramite il dispositivo RIGENERACONS , il paziente diventa sia donatore che accettore in un unico tempo chirurgico.

 
BIBLIOGRAFIA

 

Biologia di base

 

AUTORE NAZIONE TITOLO PUBBLICAZIONE ANNO
Trovato L, Monti M, Del Fante C, Cervio M, Lampinen M, Ambrosio L, Redi CA, Perotti C, Kankuri E, Ambrosio G, Rodriguez Y Baena R, Pirozzi G, Graziano A. ITALIA A new medical device Rigeneracons allows to obtain viable micro-grafts from mechanical disaggregation of human tissues J Cell Physiol  2015
Purpura V, Bondioli E, Graziano A, Trovato L, Melandri D, Ghetti M, Marchesini A, Cusella de Angelis MG, Benedetti L, Ceccarelli G, Riccio M. ITALIA Tissue characterization after a new disaggregation method for skin micro-grafts generation J Vis Exp  2016
Svolacchia F, De Francesco F, Trovato L, Graziano A, Ferraro GA. ITALIA An innovative regenerative treatment of scars with dermal micrografts J Cosmet Dermatol  2016
Monti, M., Graziano, A., Rizzo, S., Perotti, C., Del Fante, C., d'Aquino, R., Redi, C. A. and Rodriguez y Baena, R. ITALIA In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental Pulp J. Cell. Physiol. 2016
Noda S., Sumita Y., Ohba S., Yamamoto H., Asahina I. JAPAN Soft Tissue Engineering with Micronized-Gingival Connective Tissues J. Cell. Physiol. 2017
Lampinen M., Nummi A., Nieminen T., Harjula A. and Kankuri E. FINLAND Intraoperative processing and epicardial transplantation of autologous atrial tissue for cardiac repair Transplantation of autologous atrial micrografts Journal of Heart and Lung Transplantation  2017
Jimi S., Kimura M., Di Francesco F., Riccio M., Hara S., and Ohjimi H. JAPAN Acceleration mechanisms of skin wound healing by autologous micrograft in mice International Journal of Molecular Science  2017

Wound care

 

AUTORE NAZIONE  TITOLO PUBBLICAZIONE ANNO
Giaccone M, Brunetti M, Camandona M, Trovato L and Graziano A ITALIA A New Medical Device, Based on Rigenera Protocol, in the Management of Complex Wounds J Stem Cells Res, Rev & Rep. 2014
Marcarelli, M., Trovato, L., Novarese, E., Riccio, M. and Graziano, A. ITALIA Rigenera protocol in the treatment of surgical wound dehiscence Int Wound J. 2016
Baglioni E, Trovato L, Marcarelli M,Frenello A, Bocchiotti MA. ITALIA Treatment of Oncological Post-surgical Wound Dehiscence with Autologous Skin Micrografts Anticancer Res. 2016
Trovato L, Failla G, Serantoni S, Palumbo FP ITALIA Regenerative Surgery in the Management of the Leg Ulcers J Cell Sci Ther  2016
De Francesco, F., Graziano, A., Trovato, L. Ceccarelli, G. Romano M., Marcarelli M., deAngelis GC., Cillo U., Riccio M., Ferraro GA ITALIA A Regenerative Approach with Dermal Micrografts in the Treatment of Chronic Ulcers Stem Cell Rev and Rep 2016
Bocchiotti MA., Bogetti P., Parisi A., Rivarossa F., Frenello A., Baglioni EA ITALIA Management of Fournier's gangrene non-healing wounds by autologous skin micrograft biotechnology: a new technique J Wound Care 2017
Miranda R., Farina E., Farina MA. ITALIA Micrografting chronic lower extremity ulcers with mechanically disaggregated skin using a micrograft preparation system Jl of Wound care 2018
  
Ortopedia

 

AUTORE NAZIONE   PUBBLICAZIONE ANNO
Dorta Fernández A, Luengo AB SPAGNA Biostimulation of Knee Cartilage Using Autologous Micro-Grafts: A Preliminary Study of the Rigenera Protocol in Osteochondral Lesions of the Knee. Rehabilitation Sciences.  2018
 
Medicina Estetica e Plastica

 

AUTORE NAZIONE TITOLO PUBBLICAZIONE ANNO
Zanzottera F, Lavezzari E, Trovato L, Icardi A, Graziano A. SVIZZERA Adipose Derived Stem Cells and Growth Factors Applied on Hair Transplantation. Follow-Up of Clinical Outcome.  JCDSA 2014
Svolacchia F, De Francesco F, Trovato L, Graziano A, Ferraro GA. ITALIA An innovative regenerative treatment of scars with dermal micrografts. J Cosmet Dermatol  2016
Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V ITALIA A combined use of Chondrocytes Micro Grafts (CMG) Mixed with Platelet Rich Plasma (PRP) in Patients Affected by Pinch Nose Deformity. J Regen Med 2016
Gentile P, Scioli MG, Bielli A, Orlandi A,  Cervelli V. ITALIA Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss. Stem Cell Investig 2017
Ceccarelli G., Gentile P., Marcarelli M., Balli M. Ronzoni F.R, benedetti L., Cusella De Angelis MG. ITALIA In Vitro and In Vivo Studies of Alar-Nasal Cartilage Using Autologous Micro-Grafts: The Use of the Rigenera® Protocol in the Treatment of an Osteochondral Lesion of the Nose Pharmaceuticals  2017
Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V ITALIA Comparing different nanofat procedures on scars: role of the stromal vascular fraction and its clinical implications Regen. Med 2017
Álvarez et al. SPAGNA Microscopic and histologic evaluation of the Rigenera ® method for the treatment of Androgenetic alopecia in a small number of cases. International Journal of Research Studies in Medical and Health Sciences.  2017
Álvarez et al.  SPAGNA Clinical and histological evaluation of the Rigenera® method for the treatment of androgenetic alopecia. International Educational Applied Scientific Research Journal.  2018
Hernan Pinto, Rafael Galvez, Josè Casanova. SPAGNA Dermoscopy Is the Crucial Step for Proper Outcome Prospection When Treating Androgenetic Alopecia with the Rigenera®. Protocol: A Score Proposal International Journal of Clinical and Developmental Anatomy. 2018
 
Maxillo

 

autore nazione titolo pubblicazione anno
Rodriguez y Baena R, D’Aquino R, Graziano A, Trovato L, Aloise AC, Ceccarelli G, Cusella G, Pelegrine AA and Lupi SM ITALIA Autologous Periosteum-Derived Micrografts and PLGA/HA Enhance the Bone Formation in Sinus Lift Augmentation. Front. Cell Dev. Biol. 2017
Monti, M., Graziano, A., Rizzo, S., Perotti, C., Del Fante, C., d'Aquino, R., Redi, C. A. and Rodriguez y Baena, R. ITALIA In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental Pulp. J. Cell. Physiol. 2016
D’Aquino R, Trovato L, Graziano A, Ceccarelli G, de Angelis GC, et al ITALIA Periosteum-derived micro-grafts for tissue regeneration of human maxillary bone. J TranslSci 2016
Aimetti M, Ferrarotti F, Cricenti L, Mariani GM, Romano F. ITALIA Autologous dental pulp stem cells in periodontal regeneration: a case report. Int J Periodontics Restorative Dent. 2014
Rodriguez R, D’Aquino R, Trovato L, Graziano A ITALIA A Human Tissue Regeneration in Maxillo-facial Area: From Stem Cells to Micrografts Current Tissue Engineering 2014
Graziano A, Carinci F, Scolaro S, D'Aquino R. ITALIA Periodontal tissue generation using autologous dental ligament micro-grafts: case report with 6 months follow-up. AOMS. 2013
Brunelli G, Motroni A, Graziano A, D'Aquino R et al. ITALIA Sinus lift tissue engineering using autologous pulp micro-grafts: A case report of bone density evaluation. J Indian Soc Periodontol 2013
Aimetti M, Ferrarotti F, Mariani GM, Cricenti L, Romano F. ITALIA Use of Dental Pulp Stem Cells/Collagen Sponge Biocomplex in the Treatment of Non-contained Intrabony Defects: A Case Series. Clinical Advances in Periodontics, 2013
Riccardo d’Aquino, Alfredo De Rosa, Vladimiro Lanza, Virginia Tirino, Luigi Laino, Antonio Graziano, Vincenzo Desiderio, Gregorio Laino and Gianpaolo Papaccio. ITALIA Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. European Cells and Materials 2009